Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst

http://repository.vnu.edu.vn/handle/11126/13124

Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. 

In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…).

The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. 

Title:	Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst
Authors:	Lưu, Văn Bôi Phạm, Hoài Thu Nguyễn, Vũ Quang Thành Doãn, Thu Hồng Nguyễn, Bích Ngọc Vũ, Thị Huệ Mạc, Đình Hùng
Issue Date:	2013
Publisher:	H. : ĐHQGHN
Citation:	7 tr.
Abstract:	Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. .
URI:	http://repository.vnu.edu.vn/handle/11126/13124
Appears in Collections:	Natural Sciences and Technology