Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis

http://repository.vnu.edu.vn/handle/VNU_123/11205

The etiology and pathophysiology of inflammatory bowel disease (IBD), which is a multifactorial disorder, remain poorly understood.

Curcuma longa extract has been demonstrated to exhibit anti-inflammatory activity in the literature.

Here, we examined the effect of C. longa extract on dextran sulfate sodium (DSS)-induced colitis over a period of 7 days.

The extract (150 mg/kg/b.w.) was mixed with the diet of the mice. C. longa significantly reduced the Disease Activity Index and myeloperoxidase activity.

 The extract also suppressed the levels of pro-inflammatory IL-1β, IL-6, IL-17, INFγ, TNF-α and increased the level of IL-10.

Additionally, the protein expression levels of COX-2 and iNOS were reduced by C. longa extract.

Our results suggest that C. longa extract exerts beneficial effects on experimental colitis; therefore, we propose that this extract may have therapeutic implications for ulcerative colitis.

Title:	Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis
Authors:	Bui, Thanh Tung Nguyen, Thanh Hai Le, Thi Thu Huong Duong, Thi Ly Huong
Keywords:	Curcuma longa extract;Colitis;DSS;Inflammation;Mice
Issue Date:	2014-10
Publisher:	Merit Research Journal of Medicine and Medical Sciences
Citation:	Tung Bui Thanh, Hai Nguyen Thanh, Huong Le-Thi-Thu and Huong Duong Thi Ly (2014). Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis. Merit Research Journal of Medicine and Medical Sciences Vol. 2(10) pp. 216-224, October, 2014
Abstract:	The etiology and pathophysiology of inflammatory bowel disease (IBD), which is a multifactorial disorder, remain poorly understood. Curcuma longa extract has been demonstrated to exhibit anti-inflammatory activity in the literature. Here, we examined the effect of C. longa extract on dextran sulfate sodium (DSS)-induced colitis over a period of 7 days. The extract (150 mg/kg/b.w.) was mixed with the diet of the mice. C. longa significantly reduced the Disease Activity Index and myeloperoxidase activity. The extract also suppressed the levels of pro-inflammatory IL-1β, IL-6, IL-17, INFγ, TNF-α and increased the level of IL-10. Additionally, the protein expression levels of COX-2 and iNOS were reduced by C. longa extract. Our results suggest that C. longa extract exerts beneficial effects on experimental colitis; therefore, we propose that this extract may have therapeutic implications for ulcerative colitis.
URI:	http://repository.vnu.edu.vn/handle/VNU_123/11205
ISSN:	2354-323X
Appears in Collections:	SMP - Papers / Tham luận HN-HT